The repertoire of αβ T cell antigen receptors (TCRs) on mature T cells is selected in the thymus where it is rendered both self-tolerant and restricted to the recognition of major histocompatibility ...
T cells are a critical part of the adaptive immune system that respond to pathogens, tumors, or play a key role in autoimmune diseases. A T cell recognizes potential targets through its T cell ...
To enhance CAR T therapies, scientists are actively studying TCR signaling and T-cell exhaustion mechanisms to improve CAR T persistence and function. Additionally, there is a growing trend towards ...
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Review highlights emerging role of tumor MHC-II in shaping cancer immunotherapy outcomes
Cancer immunotherapy has transformed cancer treatment, yet many patients experience limited or short-lived responses due to ...
Major histocompatibility complex class II (MHC-II) molecules play a critical, yet historically overlooked, role in tumor ...
CD3 (including its subunits CD3ε, CD3δ, CD3γ, and CD3ζ) is the central component of the TCR-CD3 complex and is crucial for recognizing T cells and responding to antigens. Every subunit of CD3 has ...
Yang X*, Nishimiya D*, Lochte S, Jude KM, Borowska M, Savvides CS, Dougan M, Su L, Zhao X, Piehler J, Garcia KC. (2023) Facile repurposing of peptide-MHC restricted ...
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